Gas or Diesel?
I have a F450 7.3 Powerstroke Diesel. 15,000 GVW.
16 MPG running empty without trailer.
11 MPG pulling 34 foot Gooseneck at about 12,000 trailer weight.
9 MPG in the Pacific NW mountains pulling the trailer.
Duramax in the 4500 GMC likly will do better.
If the 4500 is not a Duramax, keep shopping.
Check out the GVW of the truck, what is on the stickers in the door jam, not what the truck is licensed for. If you have never owned a 16,000 GVW or over truck, carfefully research your state regs concerning Commercial Vehicles, CDL, stoping at scales, medical exam required for the CDL, etc. Some states are nasty about all this stuff. Then the Federal DOT steps in and things get more complicated. Logbook required, scale stops required, etc. And some states go for the total combined weight of truck and trailer, it is real easy to go go over 20,000 GVW if the trailer is loaded, especially in your case when moving iron! The key here is if the truck is used for commerce. If you are making money with the truck, i.e., transporting for buying and selling, then you are classified commercial and have to follow all the rules.
16,000 GVW is where most states, and the Feds, make you follow the commercial truck rules. Some states are lobbying to go to 10,000 GVW so as to eliminate the loophole of hotshot truckers using F350's, Dodge and GM 3500's for commercial haul.