In the late 70s through the middle 80s there was a surge of interest in putting Python barrels onto other revolver frames. The most common were Smith & Wesson conversions (referred to as a "Smolt"), but there were a few people doing Ruger conversions ("Couger.")
The Python was, at that time, the most accurate factory revolver that you could buy, so it was somewhat natural to try and bring that accuracy to other guns. The Python barrels had a faster twist rate, along with a slightly conical bore and proprietary forcing cone angle. It was thought that putting a Colt barrel on a lesser gun might yield a satisfactory result.
Another factor was the impression that the Python was somehow less durable than the S&W and Ruger, and that the Colt trigger pull was different than the other two. (Colts increase pull weight toward the end of their travel, while S&W and the Ruger "Six" series were somewhat more linear.) That the Python was the only readily available gun at the time with a full underlug, and that barrel just looked better than the stock offerings from the other makers, was icing on the cake.
The first objection was not well-founded*, and the second was easily dealt with by any number of good gunsmiths of the day. However, most of the revolversmiths operating in that era weren't really qualified to work on the Colt lockwork, so it was easier for them to simply fit a barrel.
The resulting guns were, by all accounts, more accurate than their parents, but still wouldn't out-shoot a Python in native trim. Aside from the fact that most of the barrels weren't properly fitted (Colt fits theirs differently, and not a lot of people knew what those differences were), there was something that the S&W and Ruger frames could never achieve: the Colt's justly famed "bank vault" cylinder lockup. That was responsible for the last little bit of accuracy that often put put the Python over the top.
The conversion craze ended with the ascendency of the Dan Wesson revolvers, which gave better-than-Python accuracy but could be had off the dealer's shelf, and with the introduction of the full-lugged "L" frames from S&W and the GP-100 which eliminated any aesthetic advantage (at least in some people's minds.) The Smolts and Cougers fell by the wayside.
Today, I know of no one who does the conversions. The labor cost and knowledge drought of properly fitting a Python barrel is a factor, but more important is the fact that Colt isn't making Python barrels any longer. Those out in the secondary market increase in value on a seemingly daily basis.
I occasionally get a call from someone eager to have a Smolt or a Couger made up from "scratch", but the quoted cost - including the acquisition of a hard-to-get barrel - always drives them away.
-=[ Grant ]=-
(*
see this link for more on the "delicacy" of Pythons.)