DNC-X won't run on 64 bit Linux, but seems to work OK on 32 bit. I just installed Linux Mint (version LMDE 4 Debbie 32 bit) on an old XP laptop and everything seems to work.
Also, here's a link to a useful article re interrupt triggers:
Fanuc, RS232, Cables, Flow Control and easyDnc. - Denford...