I've got a 2000 F250 with V10...
and it is a pretty good truck. I have teh 3.70 rearend, so it does tend to hunt a bit between OD and 3rd gear. On the HWY at 70 MPH, I'll see about 14 MPG unloaded. Around town, 10.5-12.0 MPG depending on how much start and stop.
Pulling 13,000 lbs on a gooseneck at about 65 mph on a country, uphill, downhill road, I get about 8.5 MPG. Lately, I've been pulling my 6X10 enclosed trailer around ALOT and I get about 9.5 MPG.
So, it is not great, but you can just keep loading it up and it will pull. I feel it gets a bit winded on hills. I would love to try a diesel to compare them, but have not had the opportunity to drive one. It is nice that you don't have to do all the maintenance that the diesels require: lot's of oil for changes, fuel filter changes, moisture separators, etc. Just fill it up and go. Takes 6 quarts of oil.
I would do it again. If you pull ALOT, I would look at the diesel. If you just want a good truck that you can't kill and will carry a ton of weight and take a beating. Just my 0.02.