Short answer DO NOT DO IT..
Quite a bit higher pressure... .45 Colt 13,000 psi max, Ruger and Contenders ONLY can run 25,000. The .45 brass is weaker, and should not be loaded above 25,000 psi.
Avg 44 Mag max pressure allowed is 36,000 psi .454 is up to 65,000 psi
What part of NO is not clear???
.454's are made with TOP NOTCH STEELS, HEAVY FRAMES... 1990's tech
Not a 1870's tech caliber..
A Virginian is a fine revolver, just not designed to run at double(.44) to quadruple (.45) pressures..
Look at a Freedom Arms .454 frame and see how massive it is...
Opening up a cylinder to accept .454 invites instant dissassembly. If it fits, someone will try to shoot a hot .454 out of it...