I made some small 1/4" dia x 3/4" long pins out of an Inconel based alloy ( a superalloy aircraft blade material actually ) that needed a 4-40 thread in one end. The pins were tested in a solution that simulated body fluids and a electrical charge was used to speed up the process. I started out with standard tap drill, no go, I gradually went bigger on the tap drill with the customers permission until I was able to tap the material. If I recall a 4-40 tap measures .114" and a tap drill is .089", I kept going bigger with the tap drill until I could thread it---at .113"! .0005" per side thread. Looking at a part you couldn't tell if it was threaded or not unless you tried a 4-40 bolt in the hole. I have no idea why this is relevant here, maybe cabin fever.